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News from APO|APE News: Cancer care, diagnostic pathology, and precision medicine.

International LGLL Consortium Publishes Consensus Criteria for Diagnosis, Treatment Initiation and Response Assessment in T-LGL Leukemia

Summit and Akeso Land HARMONi in The Lancet Oncology as Ivonescimab Beats Durvalumab on Survival in a China Biliary Tract Cancer Trial

DNA Methylation Epitypes Sort 1,262 De Novo AML Patients and Catch Mutation Mimics That Genetic Testing Misses

McKesson Signs Agreement to Acquire Precision Medicine Group for Approximately $2.25 Billion

FDA Approves Jazz's Bispecific HER2 Antibody Ziihera, With and Without BeOne's Tevimbra, for First-Line HER2-Positive Gastroesophageal Adenocarcinoma

Ataraxis AI Laboratory Receives CAP Accreditation and a California Clinical Laboratory License, Opening Ataraxis Breast to the State

Allegheny Health Network and The START Center for Cancer Research Will Put an Early-Phase Trial Site Inside Allegheny General Hospital

TwinStrand and the University of Washington Win a $245.2 Million Final Judgment Against Guardant Health, Which Says It Will Appeal

Pathology Foundation Models Plus Semi-Supervised Curation Detect Perineural Invasion in Colon, Prostate and Pancreatic H&E Slides

Pattern Computer and MCW Report Early Results for a Three-Second Saliva Cancer Screen, With 91% Specificity and 44% Sensitivity

FDA Grants Fast Track Designation to Erasca's Oral Pan-RAS Molecular Glue ERAS-0015 for Metastatic Pancreatic Adenocarcinoma

Elacestrant Plus Everolimus Delivers 8.3-Month Median PFS After CDK4/6 Inhibitor Progression in the ELEVATE Umbrella Study

European Commission Approves Gilead's Trop-2 ADC Trodelvy Plus Keytruda for First-Line PD-L1-Positive Metastatic Triple-Negative Breast Cancer

Periductal Myxoid Stroma on the Diagnostic H&E Slide Identifies DCIS at Risk of Invasive Recurrence in the SweDCIS Trial

Sanofi to Lay Off 229 Blueprint Medicines Workers in Massachusetts, 13 Months After the $9.1 Billion Acquisition

Radiopharm Theranostics Clears Safety Review to Open 180 mCi Cohort in 177Lu-RAD202 HER2 Radioligand Trial

Lustgarten Foundation Directs $22.8 Million to 18 Pancreatic Cancer Projects, Led by KRAS Interception and Early-Detection Trials

China's NMPA Accepts Leads Biolabs' PD-L1/4-1BB Bispecific Opamtistomig for Review in Neuroendocrine Carcinoma

Ipsen Completes Kartos Therapeutics Acquisition, Adding Phase III MDM2 Inhibitor Navtemadlin in Myelofibrosis

FDA Issues a Third Complete Response Letter for Xspray Pharma's Amorphous Dasatinib Dasynoc

FDA Grants Nuvation Bio's Mutant-IDH1 Inhibitor Safusidenib Fast Track Designation for IDH1-Mutant Glioma

FDA Grants Accelerated Approval to Replimune's Oncolytic Viral Therapy Tudriqev for Anti-PD-1 Refractory Melanoma

FDA Approves Orca Bio's Donor-Derived Regulatory T Cell Therapy Tregzi for Matched-Donor Transplant in Blood Cancers

Enhertu Improves Progression-Free Survival Over Pembrolizumab Plus Chemotherapy in First-Line HER2-Mutant NSCLC in DESTINY-Lung04

European Commission Approves Johnson & Johnson's Teclistamab With Daratumumab for Relapsed or Refractory Multiple Myeloma

Cytek Prevails on Three of Four Claims in Beckman Coulter Flow Cytometry Patent Trial, Will Contest $56M Award

Craif Raises $33 Million Series D to Bring Its Urine microRNA Cancer Test to the US and File a Pancreatic Cancer Diagnostic in Japan

Cerenome Pairs Reyobiq Intrathecal PK Data With a CNSide Cost-of-Care Model at the SNO/ASCO CNS Metastases Conference

Biokin's EGFRxHER3 Bispecific ADC Iza-bren Meets PFS Endpoint in China Phase 3 in EGFR-Mutant NSCLC

Alvotech and Lotus Pharmaceutical Sign Semi-Exclusive US Deal for Proposed Durvalumab Biosimilar AVT34, Plus Eight Asian Markets

AbbVie Lines Up 11 WCLC 2026 Presentations Led by an Oral on the PD-1/VEGF Bispecific ABBV-1480

Isolated Deep Submucosal Invasion Preceded Lymph Node Metastasis in 12.9 Percent of T1 Colorectal Cancers

Ultrasensitive ctDNA Turned Positive Before Every Esophageal Recurrence in a 36-Patient Cohort

Liquid Biopsy Caught EGFR C797S in a Patient Progressing on Zipalertinib, a First Outside the Laboratory

A Columbia Group Puts CAR T Cell TNF Upstream of the Macrophages That Drive Cytokine Release Syndrome

Sequencing Batch Effects Moved Copy-Number Fold Changes Across 1,454 Runs at a Seoul Pathology Lab

Loss of Polarity and Dual p16 and Ki-67 Positivity Predicted Neoplasia in Atypical Glandular Cell Cytology

A Six-Protein Serum Profile Taken Before Infusion Separated Melanoma Patients Who Benefited From Unconditioned TIL Therapy

Five Australian Clinicians Set Out When to Escalate, Pause and Restart 177Lu-PSMA Rather Than Run Six Fixed Cycles

Dimeric FAP Radioligand 177Lu-D7ND Reaches Its First Five Patients After Complete Remissions in Xenografts

A Tata Memorial Review Sorts KRAS Resistance Into Four Routes and Puts Next-Generation G12C Response at 45% to 55%

West Cancer Center Wins IRB Approval to Enroll in IceCure's ChoICE Breast Cryoablation Study

Gilteritinib, Venetoclax and Azacitidine Produce 60.5 Percent Composite Remission in Relapsed FLT3-Mutated AML

BioNTech Books a Late-Breaking Slot in Seoul for the First Lung Cancer Data Pairing a PD-L1xVEGF Bispecific With an ADC

City of Hope and PeproMene Bio Report BAFF-R CAR T-Cell Therapy in Relapsed B-Cell Lymphomas

Osaka Group Reports Its Accelerator BNCT Experience in About 200 Head and Neck Cancer Cases

A Molecular Tumor Board Reached for a RAF and MEK Clamp in RAF1 S257L Colorectal Cancer Complicated by Gaucher Disease

Pillar Biosciences Panel Validated at LSI Medience for LC-SCRUM-Asia Blood Screening in Lung Cancer

IDEAYA and Genentech to Pair IDE892 With KRAS G12D Inhibitor in MTAP-Deleted Pancreatic Cancer

Hematogenix Flow Cytometry Assay Named in the Label Behind the Accelerated Approval of Zenbexus

Fine-Needle Aspiration Reaches 93.7% Sensitivity in Secondary Gastrointestinal Malignancy, 25-Year Series Finds

FDA Grants Breakthrough Therapy and Fast Track to Norroy's CAIX-Targeted PET Agent 68Ga-NYM096 in Clear Cell Kidney Cancer

Fox Chase Finds Year-Long Treatment-Free Intervals After Enfortumab Vedotin Is Stopped for Toxicity or Response

Guy's and St Thomas' Refined a Rules-Based Decision Support Platform Until It Matched Its Own Breast MDT on 250 Cases

China's Clinical Oncology Society Sets 12 GRADE-Rated Recommendations for Antiangiogenic TKIs in Sarcoma

Off-the-Shelf Base-Edited CAR33 T Cells Miss Primary Endpoints in First-in-Human AML Trial

Dual-Center Ultrasound Radiomics Model Predicts Complete Response to Neoadjuvant Chemotherapy in 659 HER2-Positive Breast Cancers

A 77-Year-Old Woman Met the Lupus Criteria and Turned Out to Have Primary Splenic Diffuse Large B-Cell Lymphoma

Pembrolizumab After Platinum Linked to Longer Survival in 147 Uterine Carcinosarcoma Patients

End-of-Consolidation MRD Predicts Survival in Pediatric Core-Binding Factor AML, Taiwan Group Reports

Merck Signs On to Sarah Cannon Research Institute Delivery Model for Community-Site Oncology Trials

Inspirata AI Reports Record Second Quarter as Five Academic Cancer Centers Adopt Its Registry Platform

Immatics Replaces the SUPRAME Interim Analysis With a Single Final Readout and Enlarges the Trial for Survival

Cesium-131 Tiles Placed at Resection Held Early Glioblastoma Regrowth to 6% in Phase I GESTALT Trial

FDA Grants Fast Track Designation to Pliant's Oral Integrin Inhibitor PLN-101095 for Checkpoint-Refractory Solid Tumors

CARsgen Books RMB62 Million in First-Half Revenue in Its First Period With Satri-cel on the Market

BeOne Medicines and The Max Foundation Renew Donated BRUKINSA Program for CLL Through 2028

SAFFRON Phase III: Tagrisso Plus Orpathys Improves Progression-Free and Overall Survival in MET-Driven EGFR-Mutated Lung Cancer After Tagrisso

Ivonescimab's HARMONi-6 Progression-Free Survival Benefit Narrows With Longer Follow-Up on New China Label, Days After Third NMPA Approval

Tomsk Review Says Integrative Tumor Microenvironment Models Outperform Single Biomarkers for Predicting Immunotherapy Response in Gastric Cancer

